
Risk of Breast Cancer in the Nurses' Health Study: Applying the Gail Model
Karen A. Johnson, MD
National Cancer Institute Bethesda, Md
Linda Williams Pickle, PhD
National Center for Health Statistics Hyattsville, Md
JAMA. 1993;270(24):2925-2926.
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To the Editor.
—The JAMA report by Colditz et al1 is an important addition to the literature on breast cancer risk assessment. Conspicuously absent from the cited references was a previous landmark article from Gail et al,2 at the National Cancer Institute, reporting a model for estimating individual absolute breast cancer risk, based on the Breast Cancer Detection Demonstration Project (BCDDP). The availability of information from the Nurses' Health Study (NHS) cohort begs for comparison with the Gail model.
Starting with initial cohorts that were similar in size, there were 2852 incident cases for analysis from the BCDDP data compared with 2389 from the NHS. The BCDDP analysis was restricted to white subjects and the NHS population was characterized as predominantly white. Both analyses controlled for established risk factors by multivariate models.
Despite the similarity of the study cohorts, there are important differences between the results from the
. . . [Full Text PDF of this Article]
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