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IV. How to Use an Article About Harm

Mitchell Levine, MD, MSc; Stephen Walter, PhD; Hui Lee, MD, MSc; Ted Haines, MD, MSc; Anne Holbrook, MD, PharmD, MSc; Virginia Moyer, MD, MPH; Evidence-Based Medicine Working Group; Gordon Guyatt, MD, MSc; Eric Bass, MD, MPH; George Browman, MD, MSc; Deborah Cook, MD, MSc; Michael Farkouh, MD; Hertzel Gerstein, MD, MSc; Ted Haines, MD, MSc; Brian Haynes, MD, MSc, PhD; Robert Hayward, MD, MPH; Anne Holbrook, MD, PharmD, MSc; Roman Jaeschke, MD, MSc; Elizabeth Juniper, MCSP, MSc; Andreas Laupacis, MD, MSc; Hui Lee, MD, MSc; Mitchell Levine, MD, MSc; Virginia Moyer, MD, MPH; David Naylor, MD, DPhi; Jim Nishikawa, MD; Andrew Oxman, MD, MSc, FACPM; Ameen Patel, MD; John Philbrick, MD; Scott Richardson, MD; Stephane Sauve, MD, MSc; David Sackett, MD, MSc; Jack Sinclair, MD; Brian Strom, MD, MPH; K S, Trout, FRCE; Sean Tunis, MD, MSc; Stephen Walter, PhD; John Williams, Jr, MD, MHS; Mark Wilson, MD, MPH

JAMA. 1994;271(20):1615-1619.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CLINICAL SCENARIO

You are having lunch in the hospital cafeteria when one of your colleagues raises the issue of the safety of β-adrenergic agonists in the treatment of asthma. Your colleague feels uncertain about how to respond to patients asking him about media reports of an increased risk of death associated with these medications. Another colleague mentions a key article on this topic that generated much of the publicity, but she cannot recall the details. You all agree that this is an issue that arises frequently enough in your practices that you should become familiar with the evidence contained in the article that your patients have heard about. You volunteer to search the literature for the key article and report back to your colleagues in the next few days.

THE SEARCH

The next day you do a MEDLINE search using the following terms: asthma (MH) (MH stands for MeSH heading, . . . [Full Text PDF of this Article]

Author Affiliations
From the Departments of Clinical Epidemiology and Biostatistics (Drs Levine, Walter, and Haines), Medicine (Drs Lee and Holbrook), the Occupational Health Program (Dr Haines), McMaster University, Hamilton, Ontario; and the Department of Pediatrics, University of Texas, Houston (Dr Moyer).

Footnotes
A complete list of members (with affiliations) of the Evidence-Based Medicine Working Group appears in the first article of this series (JAMA. 1993;270:2093-2095). The following members contributed to this article: Gordon Guyatt (chair), MD, MSc; Eric Bass, MD, MPH; George Browman, MD, MSc; Deborah Cook, MD, MSc; Michael Farkouh, MD; Hertzel Gerstein, MD, MSc; Ted Haines, MD, MSc; Brian Haynes, MD, MSc, PhD; Robert Hayward, MD, MPH; Anne Holbrook, MD, PharmD, MSc; Roman Jaeschke, MD, MSc; Elizabeth Juniper, MCSP, MSc; Andreas Laupacis, MD, MSc; Hui Lee, MD, MSc; Mitchell Levine, MD, MSc; Virginia Moyer, MD, MPH; David Naylor, MD, DPhi; Jim Nishikawa, MD; Andrew Oxman, MD, MSc, FACPM; Ameen Patel, MD; John Philbrick, MD; Scott Richardson, MD; Stephane Sauve, MD, MSc; David Sackett, MD, MSc; Jack Sinclair, MD; Brian Strom, MD, MPH; K.S. Trout, FRCE; Sean Tunis, MD, MSc; Stephen Walter, PhD; John Williams Jr, MD, MHS; and Mark Wilson, MD, MPH.

Reprint requests to Room 2C12, McMaster University Health Sciences Centre, 1200 Main St W, Hamilton, Ontario, Canada, L8N 3Z5 (Dr Guyatt).

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