This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Michio Hirano, MD; Jeffrey G. Odel, MD; Norah S. Lincoff, MD
College of Physicians and Surgeons of Columbia University New York, NY

JAMA. 1994;271(9):663.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—We appreciate the comments of Hedges et al regarding our article entitled" 'Outbreak' of Optic and Peripheral Neuropathy in Cuba?" We agree with Sadun¹ and Hedges et al that it can be difficult to distinguish the Cuban optic neuropathy from functional vision loss; in fact, some of the Cuban "cases" might be functional. In our study, we used the following features to diagnose optic neuropathy: central or centrocecal scotoma and at least two of the following three criteria: (1) loss of visual acuity (corrected to 20/40 or worse); (2) loss of color vision (missed two or more of six American Optical Hardy-Hand-Ritter plates); and (3) temporal pallor of the optic disc. Hedges et al concur with Sadun that the critical finding in Cubans affected with optic neuropathy is "presence of nerve fiber layer (NFL) dropout in the maculopapillary bundle of the retina."

The NFL is composed of . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?