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The Critical Role of Providers

Walter A. Orenstein, MD; Roger H. Bernier, PhD, MPH

JAMA. 1994;272(14):1138-1139.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

On May 14, 1796, Edward Jenner performed the first successful vaccination against smallpox with virus obtained from a woman infected with cowpox. In the almost 200 years since that sentinel event, smallpox has been eradicated and polio has been eliminated from the Americas. Sophisticated biotechnology has brought us hepatitis B vaccine, the first licensed vaccine developed using recombinant DNA techniques. New technology has permitted linkage of Haemophilus influenzae type b capsular polysaccharide to protein carriers to improve the immune response of infants, and H influenzae type b invasive disease has been reduced by more than 95% in the 5 years since introduction of the first conjugate vaccines.¹ As reported by Granoff et al² in this issue of THE JOURNAL, research continues into improving the already excellent immune response to these conjugate vaccines.

While much more remains to be done in developing new and improved vaccines, the system of . . . [Full Text PDF of this Article]

Author Affiliations
From the National Immunization Program, Centers for Disease Control and Prevention, Atlanta, Ga.

Footnotes
Reprint requests to National Immunization Program, Centers for Disease Control and Prevention, 1600 Clifton Rd, Mailstop E-05, Atlanta, GA 30333 (Dr Orenstein).

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