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Scientific Scrutiny and Ethical Responsibility

Peter A. Patriarca, MD

JAMA. 1994;272(21):1700-1701.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Influenza viruses have arguably caused more morbidity and mortality than any infectious agent in recorded history. Seven pandemics of influenza have occurred during the past century alone, one of which—the infamous Spanish (swine) flu—was responsible for at least 20 million deaths worldwide. Of even greater concern has been the occurrence of annual epidemics of varying severity that have resulted in more than 599 000 excess deaths in the United States during the past 40 years.^1-3 Although complacency regarding influenza is widely prevalent owing to the misperception that it is simply a mild respiratory or gastrointestinal infection,² one needs only to briefly examine accounts of recent outbreaks to appreciate the explosive potential for influenza viruses to cause life-threatening illness.⁴ The unusual properties of the virus' genome, including a high frequency of point mutations (which cause the hemagglutinin [HA] and neuraminidase [NA] molecules to drift

See also p 1661. . . . [Full Text PDF of this Article]

Author Affiliations
From the Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Md.

Footnotes
Corresponding author: Peter A. Patriarca, MD, Food and Drug Administration, HFM-30, 1401 Rockville Pike, Rockville, MD 20852.

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