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Steven D. Douglas, MD

JAMA. 1994;272(6):487-488.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

There will be more than 15 million women infected with human immunodeficiency virus type 1 (HIV-1), 3 million HIV-positive infants, and more than 2 million children with pediatric acquired immunodeficiency syndrome (AIDS) worldwide by the year 2000, according to estimated projections.¹ The rate of transmission of HIV-1 from an infected woman to her fetus or infant ranges from 13% to 32% in industrialized countries to 25% to 48% in developing countries.¹ In addition to HIV-1, a second virus causing AIDS, HIV type 2 (HIV-2) has been isolated from individuals from Guinea Bissau, The Gambia, and the Ivory Coast, West Africa. Differing from HIV-1 strains by more than 55% in sequence analysis, HIV-2 may have a different immunopathogenesis than HIV-1. In this issue of THE JOURNAL, Adjorlolo et al² report perinatal transmission in dually infected women (determined by polymerase chain reaction analysis of leukocytes) from a lower socioeconomic . . . [Full Text PDF of this Article]

Author Affiliations
From the Division of Allergy, Immunology, and Infectious Diseases, The Children's Hospital of Philadelphia (Pa), and Department of Pediatrics, University of Pennsylvania Medical School, Philadelphia.

Footnotes
Reprint requests to University of Pennsylvania Medical School, The Children's Hospital of Philadelphia, Section for Immunology, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104-4399 (Dr Douglas).

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