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Thomas Stamos, MD; Robert S. Rosenson, MD
Rush-Presbyterian-St Luke's Medical Center Chicago, Ill

JAMA. 1995;273(17):1330.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—In an article in the November 2,1994, issue of THE JOURNAL, Dr Krumholz and colleagues¹ prospectively followed 997 elderly subjects and reported no significant relationship between total cholesterol or high-density lipoprotein cholesterol (HDL-C) and cardiac events. Because the wide confidence intervals (CIs) included values greater than 1.0, this cannot be considered a negative study. In fact, the upper limit of their CI for adjusted CHD mortality for men and women (1.98) is a similar risk ratio to that reported previously in middle-aged men.²

Part of the reason for the wide CIs is likely the size of the study and short duration of follow-up. Studies establishing the relationship between hypercholesterolemia and CHD in middle-aged individuals evaluated many more subjects for greater lengths of time. For example, the Multiple Risk Factor Intervention Trial³ (MRFIT) followed 356222 subjects over a 6-year period, and the Lipid Research Clinics . . . [Full Text PDF of this Article]

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