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Heather S. Hopkins, MA; Alan J. Gelenberg, MD
University of Arizona Tucson

JAMA. 1995;273(19):1489-1490.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Dr Hollander¹ states that fluoxetine has a 1.9% incidence of sexual dysfunction, with impotence or ejaculatory problems occurring in less than 1% of patients. Although the Physicians' Desk Reference lists 1.9% as the rate of sexual dysfunction with fluoxetine,² several case series and open studies have found rates ranging from 7.8% to 75%.3 The most common sexual problem associated with fluoxetine in these reports is anorgasmia. In one survey, 60 consecutive male patients who received fluoxetine (20 mg/d) were specifically questioned about ejaculatory changes, and 45 (75%) reported retarded ejaculation or ejaculatory incompetence.³

Hollander also states that he is unaware of any information on whether fluoxetine has a direct effect on improving sexual dysfunction. There are a few reports in the literature that suggest that fluoxetine's "adverse" sexual effects may be beneficial for some patients. Stratta et al⁴ found fluoxetine helpful for two . . . [Full Text PDF of this Article]

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