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Tuula Pirttila, MD
Institute for Basic Research Staten Island, NY

Terho Lehtimaki, MD; Tapio Nikkari, MD; Harry Frey, MD; Kari Mattila, PhD
University of Tampere Tampere, Finland

JAMA. 1995;273(5):375.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—The association between apo E E4 and AD has been shown in patients with probable AD and in autopsyconfirmed AD cases. However, the specificity of apo E E4 as a risk factor for AD is not known. In a recent letter, Dr Frisoni and colleagues¹ proposed that the frequency of apo E E4 is increased also in vascular dementia compared with that in controls.

We analyzed apo E phenotypes in 30 patients with vascular dementia and 115 age-matched controls using isoelectric focusing and Western blotting as previously described.² Vascular dementia was diagnosed according to the guidelines established by the NINDS-AIREN International Workshop.³ Seventeen patients with probable vascular dementia had a typical multi-infarct dementia. Possible vascular dementia was diagnosed in 13 patients, eight of whom were considered to have mixed dementia (ie, possible AD and concomitant significant cerebrovascular disease).

No difference in apo E E4 . . . [Full Text PDF of this Article]

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