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The Etiologic Agent for Peptic Ulcer

Barry J. Marshall, MD

JAMA. 1995;274(13):1064-1066.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

UNRAVELING the puzzle of Helicobacter pylori and its pivotal role in gastric disease was not done in isolation. Many of the pieces were already available but dispersed over 100 years in journals of different languages and subspecialties. The prevailing dogma was that the stomach was sterile and that bacteria could not survive in gastric acid, but there were articles describing gastric spiral bacteria as far back as 1886.¹ Even after the advent of endoscopy, descriptions of the presence of curved organisms on the surface of the gastric mucosa were ignored by mainstream medicine.

REDISCOVERY OF H PYLORI

Fourteen years have passed since my work on H pylori began. In 1981, Robin Warren at Royal Perth Hospital in Western Australia first showed me the spiral bacteria he had discovered in patients with gastritis. Together we embarked on an attempt to culture the organisms by taking gastric biopsy specimens from patients . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, University of Virginia Health Sciences Center, Charlottesville.

Footnotes
Dr Marshall is the recipient of the 1995 Albert Lasker Clinical Medical Research Award.

Dr Marshall holds patents related to diagnosis and treatment of Helicobacter pylori and is a shareholder in several companies with similar interests.

Reprint requests to Tri-Med Specialties Inc. 1500 Avon St Ext, Charlottesville, VA 22902 (Dr Marshall).

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