This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Preimplantation Diagnosis of the Cystic Fibrosis F508 Mutation: What of the Other Two Embryos?

Charles W. Callahan, DO; Donald A. Person, MD
Tripler Army Medical Center Honolulu, Hawaii

JAMA. 1995;274(2):126-127.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Dr Liu and colleagues¹ recently reported the remarkably successful application of microsurgical techniques of epididymal sperm aspiration and intracytoplasmic sperm injection of stimulated oocytes. Following in vitro fertilization, blastomere biopsy was accomplished by micromanipulation. Analysis of DNA by polymerase chain reaction demonstrated the genotype of the embryos from two cystic fibrosis carriers.

Five embryos were successfully fertilized. Two were homozygous for the F508 genotype and three were carriers. These three carriers were transferred to the uterus and one successfully implanted. Subsequently, a phenotypically normal male infant was born.¹ The article emphasized the preimplantation diagnosis of cystic fibrosis as well as the father's diagnosis of congenital bilateral absence of the vas deferens. The study, we are told, was approved by the institutional ethics committee. It is impossible to describe the joy that comes from the blessing of parenthood. We who are parents rejoice with this new . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?