This Article  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Denis R. Henrard, PhD
Institut Pasteur Paris, France

James Goedert, MD
National Cancer Institute Rockville, Md

JAMA. 1995;274(23):1836.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—Log or square root transformation of CD4 values is quite reasonable to assess their relationship to AIDS because the relative hazard increases in a nonlinear way. The effect of such transformation on other predictive markers, however, depends on their mutual relationships. In the three-variable Cox proportional model of our baseline values, the relative hazards of AIDS were 2.59 (95% confidence interval [CI], 1.02 to 6.56) with a decrement of one log in CD4 percentage, 2.46 (95% CI, 1.04 to 5.88) with p24 antigenemia, and 1.77 (95% CI, 1.01 to 3.10) per log₁₀ HIV-1 RNA. Thus, even if there is a marginally better fit of the CD4 values, p24 log₁₀ antigenemia and HIV-1 RNA levels remain independent predictive markers of AIDS risk. . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?