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Edward L. Trimble, MD, MPH
National Cancer Institute Bethesda, Md

Vicki L. Seltzer, MD
Albert Einstein College of Medicine Bronx, NY

JAMA. 1995;274(5):383.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—Drs Foulkes and colleagues underscore a key point in the recommendations of the NIH Consensus Development Panel on Ovarian Cancer, namely, the importance of ascertaining family history to define a woman's inherited risk of ovarian, breast, colon, and other cancers. However, it is important to differentiate between those women whose pedigree fits one of the three major syndromes (site-specific ovarian cancer syndrome, breast-ovarian cancer syndrome, and Lynch II syndrome) and those in whom the appearance of ovarian cancer appears to be sporadic.¹ The vast majority (97%) of women with two or three relatives with ovarian cancer will not have a hereditary cancer syndrome.^2,3 Their lifetime probability of developing ovarian cancer appears to be about 7%. Those women whose family history is consistent with a hereditary cancer syndrome may have a lifetime risk of 40%, assuming an autosomal-dominant inheritance pattern with 80% penetrance.⁴ The development of . . . [Full Text PDF of this Article]

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