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Chris H. Bangma, MD, PhD
Ries Kranse

Fritz H. Schröder, MD, PhD
Academisch Ziekenhuis Rotterdam Rotterdam, the Netherlands

JAMA. 1996;275(11):837-838.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—We read with great interest the article by Dr Catalona and colleagues.¹ We have performed a similar study in a screening population with quite similar results.² We used a different assay (Deltia ProStatus PSA Free/Total assay of Wallac Oy Company, Turkey, Finland) that automatically measures both free and total prostate-specific antigen (PSA) equimolarly at the same time in one sample.

The most prominent conclusion from the article by Catalona et al is that percent free PSA (or free/total [F/T] ratio) increases specificity to predict positive prostate biopsies in men with prostate gland volume of 40 cm³ or more in the PSA range between 4.0 and 10.0 ng/mL at a sensitivity level of 90%. In that group, 38% of biopsies could have been avoided at the cost of 10% loss of detection, independent of the result of digital rectal examination (DRE). In the subgroup of . . . [Full Text PDF of this Article]

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