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Scott M. Whitcup, MD

JAMA. 1996;275(2):142-144.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SELECTED CASE

A 17-year-old patient with hemophilia A was diagnosed with transfusion-acquired human immunodeficiency virus (HIV) infection in 1987. Antiretroviral therapy for diminishing CD4 cell counts included zidovudine for 3 years followed by didanosine and lamivudine (known then as 3TC). An initial ophthalmic screening examination in December 1992 revealed visual acuity of 20/20 in each eye, and retinal examination showed several nerve fiber layer infarcts (cotton-wool spots) in the left eye. In November 1993 the patient had no visual complaints, but on routine eye examination, visual acuity was 20/32 in the right eye and 20/25 in the left eye. Retinal examination revealed bilateral cytomegalovirus (CMV) retinitis (Figure), and the patient was started on intravenous ganciclovir at a dose of 5 mg/kg twice daily. Other medications included rifabutin (150 mg daily), captopril (12.5 mg twice a day), digoxin (0.37 mg daily), megestrol acetate (40 mg three times a day), lamivudine (175 . . . [Full Text PDF of this Article]

Author Affiliations
From the Clinical Branch, National Eye Institute, National Institutes of Health, Bethesda, Md.

Footnotes
This article is one of a series addressing emerging and reemerging global microbial threats.

Reprint requests to National Eye Institute, 10 Center Dr, Bldg 10, Room 10N 202, Bethesda, MD 20892-1858 (Dr Whitcup).

Grand Rounds at the Clinical Center of the National Institutes of Health section editors: John I. Gallin, MD, the Clinical Center of the National Institutes of Health, Bethesda, Md; David S. Cooper, MD, Contributing Editor, JAMA.

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