This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Allen R. Walker, MD; Catherine D. DeAngelis, MD

JAMA. 1996;275(23):1841-1842.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Infections caused by penicillin- and cephalosporin-resistant Streptococcus pneumoniae are becoming important clinical problems in a number of areas of the country and of the world. [See also Infectious Diseases.—ED.] A study of invasive pneumococcal infections in children with sickle cell disease in Memphis, Tenn,¹ described 6 children who were infected with multiply-resistant pneumococcus. Two of these children died. A review of the experience in this sickle cell disease treatment center showed that 15% of the strains that caused pneumococcal sepsis during a 4-year period were resistant to penicillin. Vancomycin hydrochloride remains uniformly effective against pneumococcus, and the authors suggest that vancomycin be added to cefotaxime sodium in children with sickle cell disease who have meningitis or another "potentially serious focus of infection such as pneumonia," evidence of overwhelming infection, or a history of sepsis.

Penicillin-resistant pneumococci are generally susceptible to the serum concentrations that can be achieved with . . . [Full Text PDF of this Article]

Author Affiliations
The Johns Hopkins University School of Medicine, Baltimore, Md

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?