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Bhadrasain Vikram, MD
Albert Einstein College of Medicine of Yeshiva University Bronx, NY

JAMA. 1996;276(11):870.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—In their Editorial, Drs Page and Jensen¹ appear to be talking out of both sides of their mouths. On the one hand they underscore "the urgent need for studies of prognosis and treatment for women with DCIS," but on the other hand they castigate² the only large-scale prospective randomized study on the subject to date (the NSABP B-17 trial).^3,4 One suspects that this was because the results of that study failed to support their opinion that a subgroup of women with DCIS can be identified for whom partial-breast treatment is adequate.

The NSABP B-17 trial randomly assigned women with DCIS (median lesion size of 8 mm) to whole-breast treatment vs partial-breast treatment groups and found that partial-breast treatment was inadequate and led to a significantly greater incidence of recurrences, particularly invasive recurrences.³ Further multivariate analysis identified 2 independently significant prognostic features, involved surgical margins and comedo . . . [Full Text PDF of this Article]

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