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Yusuke Asakura, MD; Hiroshi Mohri, MD, PhD; Kenji Okuda, MD, PhD
Yokohama City University School of Medicine Yokohama, Japan

JAMA. 1996;276(16):1300.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Dr Dickover and colleagues¹ clearly demonstrated that high maternal plasma human immunodeficiency virus (HIV)—1 RNA levels correlate with perinatal transmission, and zidovudine treatment decreases risks of maternal-to-fetus transmission through reduction of HIV-1 viral load estimated by maternal plasma RNA levels.

However, although the authors cited information about the influence of viral phenotype in HIV-1 infection,^2,3 recent reports have revealed the importance of monocyte-macrophage— tropic HIV-1 isolates for establishing infections.^4,5 Thus, their conclusion, without a consideration of maternal and fetal viral phenotypes on the risks of vertical transmission, is rather dangerous; these viral tropisms should be investigated and discussed at the same time. . . . [Full Text PDF of this Article]

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