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Allison Oler, MD; Mary A. Whooley, MD
University of California, San Francisco

JAMA. 1996;276(23):1874.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—We agree with Dr Collins and colleagues that the 33% reduction in risk of MI or death in patients treated with aspirin plus heparin compared with those treated with aspirin alone was not statistically significant. The P value for the 95% CI associated with the relative risk (RR) of 0.67 (95% CI, 0.44-1.02) was.057. Athough this P value does not meet the arbitrary cutoff of.05 required for statistical significance, it suggests a low probability (5.7%) that the findings occurred by chance. We believe that these findings are strengthened by the results of 2 recent trials that compared low-molecularweight heparin plus aspirin with aspirin alone in patients with unstable angina.^1,2 In both studies, adding low-molecularweight heparin to aspirin reduced the risk of MI or death during treatment. If we had included these trials in our metaanalysis, we would have found a statistically significant summary RR of 0.56 (95% CI, 0.40-0.80). . . . [Full Text PDF of this Article]

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