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Promising Results Indicate Further Trials Required

Graham A. Colditz, MBBS, DrPH

JAMA. 1996;276(24):1984-1985.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Despite advances in diagnosis and treatment, morbidity and mortality from cancer continue to represent a major health burden. Given the potentially devastating consequences and the fear associated with a diagnosis of cancer, it is not surprising that physicians, patients, and the public may hold substantial optimism for and have considerable interest in seemingly simple and relatively easily implemented measures, such as dietary modification or use of vitamin and trace element supplementation, that appear rapidly effective for cancer prevention. Previous studies examining the potential effects of dietary supplements, such as antioxidant vitamins^1,2 for prevention of cancer, have produced mixed results. In this issue of THE JOURNAL, Clark and colleagues³ present promising but preliminary findings from a randomized trial evaluating the possible effectiveness of selenium supplementation for cancer prevention.

See also p 1957.

The Nutritional Prevention of Cancer Study by Clark et al³ randomized 1312 patients to receive placebo . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Medicine, Brigham and Women's Hospital and Harvard Center for Cancer Prevention, Harvard Medical School, Boston, Mass.

Footnotes
Corresponding author: Graham A. Colditz, MBBS, DrPH, Channing Laboratory, 181 Longwood Ave, Boston, MA 02115.

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