This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in JAMA  Social Bookmarking   What's this?

Roland E. Schmieder, MD
Universität Erlangen-Nürnberg Nürnberg, Germany

JAMA. 1996;276(7):527.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—Dr Liebson and colleagues criticized that TOMHS¹ was not included in our meta-analysis on reversal of left ventricular hypertrophy in essential hypertension. The primary goal of the meta-analysis was "to determine the ability of various antihypertensive agents to reduce left ventricular hypertrophy." In the TOMHS trial, nutritional-hygienic treatment was compared with a combination of drug treatment and nutritional-hygienic intervention. Therefore, it seems impossible to separate the effect of antihypertensive agents per se from the effects of the intensive nonpharmacological intervention plus drug therapy, since interactions between the 2 therapeutic strategies most likely occurred. For instance, nonpharmacological intervention, including restriction of dietary salt intake and reduction of overweight in combination with a diuretic, resulted in a more marked decrease of left ventricular end-diastolic diameter than with other antihypertensive drugs (-0.7 mm vs -0.3 mm; P<.02).¹ Whether the effect of the diuretic was attenuated or potentiated by the nonpharmacological . . . [Full Text PDF of this Article]

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?