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Christopher R. E. Coggins, PhD
RJ Reynolds Tobacco Company Winston-Salem, NC

JAMA. 1996;276(8):603.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Dr Pirkle and colleagues¹ suggest that further research is needed to determine the health relevance of ETS exposures that result in serum cotinine concentrations of approximately 1 ng/mL. However, Pirkle et al fail to discuss that we reported data^2-4 that show animals exposed to smoke repeatedly for 6 hours per day, with resultant mean cotinine concentrations at the end of the exposures up to 165 ng/mL, had effectively no toxicologic changes. Importantly, the particulate concentrations we used (up to 10 mg/m³) were large exaggerations of ETS concentrations (approximately 30 µ/m³) that have been reported in areas where smoking is allowed.⁵ . . . [Full Text PDF of this Article]

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