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Michael Wilschanski, MBBS; Mary Corey, PhD; Peter Durie, MD
The Hospital for Sick Children

Elizabeth Tullis, MD
Wellesley Hospital

Jerald Bain, MD; Murray Asch, MD; Brian Ginzburg, MD; Keith Jarvi, MD; Martin Buckspan, MD; Warren Hartwick, MD
Mt Sinai Hospital Toronto, Ontario

JAMA. 1996;276(8):607-608.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—The majority of adult men with cystic fibrosis (CF) are reportedly azoospermic due to congenital bilateral agenesis of the vas deferens (CBAVD), and this genital phenotype has been proposed as a diagnostic criterion for CF.^1,2 We evaluated the reproductive tract of men with CF using the following procedures: genital examinations by a specialist blinded to the patients' phenotypes and genotypes; hormone analyses (prolactin, follicle-stimulating hormone, luteinizing hormone, and testosterone); semen analyses (twice); and testicular and transrectal sonography. Genotype data were available from a previous study. Twenty-three men consented, and 20 completed all of the investigations, including 14 patients who were pancreatic insufficient (mean age, 29 years) and 6 who were pancreatic sufficient (mean age, 34 years). Thirty-five percent were homozygous for F508, and 4 of 6 patients who were pancreatic sufficient had at least 1 mild gene mutation. Secondary sexual characteristics, testicular size, and . . . [Full Text PDF of this Article]

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