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Thomas R. O'Brien, MD, MPH; Phillip S. Rosenberg, PhD; James J. Goedert, MD
National Cancer Institute Bethesda, Md

Barbara L. Kroner, PhD
Research Triangle Institute Rockville, Md

Elaine Eyster, MD
Milton S. Hershey Medical Center Hershey, Pa

JAMA. 1997;277(1):20-21.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

In Reply.

—Dr Montoro and colleagues recategorized our data and used a test for linear trend instead of the more conservative overall Mantel-Haenszel ² test that we used. They point out that subjects who received lower annual doses of non-heat-treated factor VIII concentrate (between 1978 and 1984) had somewhat higher HIV-1 RNA levels. An association between lower factor VIII dose and higher HIV-1 RNA levels would be consistent with a recent report by Montoro et al that lower factor-concentrate dose was associated with faster progression to AIDS in 225 HIV-1-infected Spanish hemophiliac patients.¹ Therefore, we examined the relationship between factor VIII dose, HIV-1 RNA levels, and time to development of AIDS in our study, the Multicenter Hemophilia Cohort Study (MHCS).

Although only a small subset of MHCS subjects were tested for HIV-1 RNA, data on factor VIII dose and clinical outcome were available for 1094 HIV-1-infected adults and children. As . . . [Full Text PDF of this Article]

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