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The Pace Accelerates

Marcelle Morrison-Bogorad, PhD; Creighton Phelps, PhD; Neil Buckholtz, PhD

JAMA. 1997;277(10):837-840.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Once considered a rare disorder, Alzheimer disease (AD) is now recognized as a major public health problem. In more than 90% of cases, AD develops after the age of 65 years (late-onset AD), with its prevalence doubling with every successive decade of life. There are cases of early-onset AD in which onset can range from the fourth decade of life until age 65 years, although these are much more rare. Despite these differences in age of onset, the clinical signature of the disease, as well as the neuropathology, is very similar in all cases. It is estimated that AD currently afflicts approximately 4 million Americans and that it occurs in nearly half of people aged 85 years and older. In addition, AD has a profound effect on the millions of spouses, relatives, and friends who make up the extensive informal network of those who provide care for people with this . . . [Full Text PDF of this Article]

Author Affiliations
From the National Institute on Aging, Bethesda, Md.

Footnotes
Reprints: Marcelle Morrison-Bogorad, PhD, Gateway Bldg 3C307, National Institute on Aging, 7201 Wisconsin Ave MSC9205, Bethesda, MD 20892-9205 (e-mail: morrisom@gw.nia.nih.gov).

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