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Baruch Modan, MD, DrPH; Eitan Friedman, MD, PhD; Galit Hirsh-Yechezkel, MSc
Chaim Sheba Medical Center Tel Hashomer, Israel

JAMA. 1997;277(12):963.

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—Our preliminary data related to the frequency of the 185delAG germline mutation in the BRCA1 gene in a subset of 79 of 585 Israeli women with ovarian cancer. Our study included 16 patients (20.3%) with borderline histopathology, none of whom carried the mutation. In subsequent extended analysis, 2 (5.6%) of 36 additional borderline cases were found to be mutation carriers (unpublished data). The latter finding is in line with the findings of 2.9% of mutation carriers having a positive family history among women with low malignant potential ovarian cancer (ie, presumably borderline) reported by Dr Shushan et al.¹ Similarly, Rubin and coworkers² reported that of 53 patients with ovarian cancer who might have been carriers of a variety of BRCA1 mutations, 3 were of a low malignant potential type.

These data indeed support the notion that the genetics of borderline ovarian tumors differ from that of the invasive . . . [Full Text PDF of this Article]

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