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Benjamin M. Tripp, MD; Thomas F. Kolon, MD; Collin Bishop, PhD; Larry I. Lipshultz, MD; Dolores J. Lamb, PhD
Baylor College of Medicine Houston, Tex

JAMA. 1997;277(12):963-964.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—Dr Palermo and colleagues¹ recently reported that when intracytoplasmic sperm injection (ICSI) was used to produce pregnancy, the pregnancies, frequency of chromosomal abnormalities, and incidence of congenital abnormalities in the babies conceived in such a manner were comparable to those conceived with standard in vitro fertilization (IVF).

Although this study is reassuring, its conclusions may lead to the injudicious, and sometimes inappropriate, use of ICSI and similar technology, ie, round spermatid nuclear injection. With the advent of ICSI combined with testicular sperm extraction as a therapeutic option, men with clinical azoospermia, who were once thought to be sterile and untreatable, now have the ability to procreate.

A major concern with ICSI is the potential transmission of genetic disease to offspring.² A host of known genetic diseases and syndromes can cause male infertility, and more are yet to be delineated. With the use of ICSI, these . . . [Full Text PDF of this Article]

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