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Contractures and Confounding: The Controversy Continues

Deborah J. del Junco, PhD

JAMA. 1997;277(20):1643-1644.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Considering the all too familiar history of conflicting evidence from independent epidemiologic studies of the health effects following exposures to various medical interventions (eg, studies of breast cancer following reserpine use¹ and of the development of rheumatoid arthritis among oral contraceptive users²), results from studies of the occurrence of connective tissue disease following breast implantation have been surprisingly consistent.^3-17 Despite the remarkable agreement showing little to no increased risk of the established connective tissue disease syndromes, the breast implant controversy has gained its own inexorable momentum. Early case reports of the development of autoimmunelike disease in women who had silicone injections directly into their breast tissue and in women who had silicone gel-filled breast implants aroused fears of a causal relationship. The fears set off a complex chain reaction of speculation about biologically plausible mechanisms, abrupt changes in Food and Drug Administration (FDA) regulatory policy, a groundswell . . . [Full Text PDF of this Article]

Author Affiliations
From the Research Service, Veterans Affairs Medical Center, Houston, Tex.

Footnotes
Corresponding author: Deborah J. del Junco, PhD, Research Service, VA Medical Center, 2002 Holcombe Blvd, Bldg 10, Room 303, Houston, TX 77030 (e-mail: deljunco@bcm.tmc.edu).

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