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XIII. How to Use an Article on Economic Analysis of Clinical Practice B. What Are the Results and Will They Help Me in Caring for My Patients?

Bernie J. O'Brien, PhD; Daren Heyland, MD; W. Scott Richardson, MD; Mitchell Levine, MD; Michael F. Drummond, PhD; for the Evidence-Based Medicine Working Group

JAMA. 1997;277(22):1802-1806.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CLINICAL SCENARIO

You recall from the first of our 2 articles¹ concerning economic analysis of clinical practice that your chief of medicine has asked you to review relevant economic evidence from the literature and report to the hospital's pharmacy and therapeutics committee, which is trying to decide on formulary guidelines for the use of streptokinase and tissuetype plasminogen activator (t-PA) in the treatment of acute myocardial infarction (AMI). Your literature search identified 2 recent key cost-effectiveness studies: an analysis of economic data collected prospectively as part of the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO) trial² of streptokinase vs t-PA by Mark et al,³ and a decision-analytic model by Kalish et al.⁴ In the first article of this 2-part series we showed you how to evaluate the validity of the different economic appraisal study methods. In this article, we will . . . [Full Text PDF of this Article]

Author Affiliations
From the Department of Clinical Epidemiology and Biostatistics, McMaster University, and Centre for Evaluation of Medicines, St Joseph's Hospital, Hamilton, Ontario (Drs O'Brien and Levine); Royal Alexandra Hospital, Edmonton, Alberta (Dr Heyland); Department of Medicine, University of Rochester, School of Medicine and Dentistry, Rochester, NY (Dr Richardson); and the Centre for Health Economics, University of York, York, United Kingdom (Dr Drummond).

Footnotes
The original list of members (with affiliations) appears in the first article of this series (JAMA. 1993;270: 2093-2095). A list of new members appears in the 10th article of the series (JAMA. 1996;275:1435-1439). The following members contributed to this article: Gordon H. Guyatt, MD, MSc (chair); Roman Jaeschke, MD, MSc; Deborah J. Cook, MD, MSc; Hertzel Gerstein, MD, MSc; Stephen Walter, PhD; John Williams, Jr, MD, MHS; and C. David Naylor, MD, MSc, DPhil.

Reprints: Gordon H. Guyatt, MD, MSc, McMaster University Health Sciences Centre, 1200 Main St W, Room 2C12, Hamilton, Ontario, Canada L8N 3Z5.

Users' Guides to the Medical Literature section editor: Drummond Rennie, MD, Deputy Editor (West), JAMA.

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