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Susan D. Ross, MD, FRCPC
Meta Works Inc Boston, Mass

JAMA. 1997;278(8):631.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

To the Editor.

—The recent review by Dr Karpfand colleagues¹ of the effect of alendronate on the incidence of nonvertebral fractures in postmenopausal women with osteoporosis presents a very clean and powerful analysis. However, the review provides no details of the search strategy or the study selection criteria, and there is no evidence that a review protocol was written a priori. Such reporting (and performance) defects have been previously noted to be widespread in published meta-analyses,² but I would have hoped that the recent evolution of the science of systematic reviews³ and the adoption of the CONSORT (Consolidated Standards of Reporting Trials) philosophy and principles⁴ might have prevented the publication of what appears to be important and well done research without these necessary details. . . . [Full Text PDF of this Article]

Footnotes
Edited by Margaret A. Winker, MD, Senior Editor, and Phil B. Fontanarosa, MD, Senior Editor.

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