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W. H. MANWARING, M.D.

J Am Med Assoc. 1921;77(11):849-852.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

The anaphylactic reaction has never been adequately analyzed from the physiologic point of view. The picture of the acute shock in any one type of animal is usually dominated by symptoms arising from some one tissue or organ. The attention of serologists has been directed almost exclusively to a study of reactions in this particular tissue, while reactions in other tissues, conceivably of even more fundamental importance, have been largely overlooked.

For example, the picture of the acute anaphylactic reaction in guinea-pigs is dominated by symptoms arising from the pulmonary tissues. Prolonged spasms of the terminal bronchioles are responsible for the dominant respiratory distress. This has directed the attention of investigators almost exclusively to a study of anaphylactic phenomena in smooth-muscle structures. Yet, aside from its dramatic rôle in guinea-pig anaphylaxis, the smooth-muscle cell is probably a relatively unimportant factor in immunity. There is reason to believe that the really . . . [Full Text PDF of this Article]

Author Affiliations
Professor of Bacteriology and Experimental Pathology, Leland Stanford Junior University School of Medicine STANFORD UNIVERSITY, CALIF.

Footnotes
Presented before the Washington University Medical Society, St. Louis, March 15, 1921.

Read before the Section on Pathology and Physiology at the Seventy-Second Annual Session of the American Medical Association, Boston, June, 1921.

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