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WARFIELD T. LONGCOPE, M.D.

J Am Med Assoc. 1921;77(20):1535-1541.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Anaphylaxis has for many years received study by those who have investigated the problems of immunity, but only within recent years has it attracted the attention of clinicians. For the problem of anaphylaxis, developed first purely by reason of its great scientific interest, has come to have, through its analogies at least, an important bearing on clinical medicine, and thus it is that considerable attention has been directed of late to the so-called idiosyncrasies or states of hypersensitiveness in man while a still more recent problem has to do with the serious effects that follow intoxication by the derivatives of native proteins.

The first serious consideration of the subject of hypersensitiveness in man really began in 1873, with the interesting observations of Blackley,¹ who studied the effect of pollens on hay-fever sufferers. He showed quite conclusively that the application of grass pollens to the nasal mucous membrane or the . . . [Full Text PDF of this Article]

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