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Intra-articular Hyaluronic Acid in Treatment of Knee Osteoarthritis: A Meta-analysis Grace H. Lo; Michael LaValley; Timothy McAlindon; David T. Felson JAMA. 2003;290:3115-3121. ABSTRACT | FULL TEXT

View larger version (39K) Figure 1. Forest Plot of Trial Effect Sizes Error bars represent 95% confidence intervals. There were 2 outlier trials20, 25 both evaluating the highest-molecular-weight hyaluronic acid. Both were industry sponsored and both showed an effect roughly equal to that of a total knee replacement. *We were unable to find the molecular weight of the hyaluronic acid formulation used in the study by Petrella et al.

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Anywhere in Article: knee replacement