THE EFFECT OF THEELIN INJECTIONS ON THE CASTRATED WOMAN

doi:10.1001/jama.1933.02740090005002

THE EFFECT OF THEELIN INJECTIONS ON THE CASTRATED WOMAN

AUGUST A. WERNER, M.D.

With Histologic Report by W. D. COLLIER, Ph.D., M.D. ST. LOUIS
From the Departments of Internal Medicine and of Pathology, St. Louis University School of Medicine.

Since this article does not have an abstract, we have provided the first 150 words of the full text.

Excerpt

The object of these experiments was to determine the effect of various dosages of theelin on human female castrates of different ages and varying length periods of castration. It was of particular interest to study the effect of this hormone on the subjective symptoms that accompany castration and on the involutionary changes that occur in the breasts and the genital tract following ovariectomy.

Stockard and Papanicolaou¹ described an exact method for following the estrual changes in the living guinea-pig by the vaginal smear. This method has been applied to the correlation of the estrual phenomena in the genital organs of the rat² and the mouse.³ Allen and Doisy,⁴ employing ovarian follicle fluid from hogs, produced pubertas praecox in immature albino rats. The vagina of the immature rat is completely closed, its external third being a solid cord of cells. They found that the injection of the

Footnotes

Because of lack of space this article is abbreviated in The Journal by the omission of a chart and the day by day reports of the cases. The complete article appears in the authors' reprints.