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JAMA. 1938;111(2):144-154. doi: 10.1001/jama.1938.72790280002008

THE PHARMACOLOGY AND THERAPEUTICS OF VITAMIN A

  1. S. W. CLAUSEN, M.D.
  1. ROCHESTER, N. Y.
  2. From the Department of Pediatrics, the University of Rochester School of Medicine and Dentistry.

Since this article does not have an abstract, we have provided the first 150 words of the full text.

Excerpt

Treatment with vitamin A is indicated in disorders clearly due to deficiency of vitamin A in the diet. These disorders include nutritional night blindness, xerophthalmia, keratomalacia and a definite kind of follicular keratosis of the skin. The use of vitamin A in the prophylaxis of these disorders is also well established. It is appropriate to discuss these well defined uses of vitamin A before undertaking an analysis of the other uses proposed for vitamin A. Tests for loss of adaptation to dim light have been introduced recently as a measure of deficiency of vitamin A. These tests are considered in the section of this review dealing with night blindness.

Treatment with vitamin A has been suggested in conditions obviously not due to deficiency, for example, in hyperthyroidism, because experiments with animals demonstrate an antagonism between vitamin A and thyroxine. Vitamin A has also been used for the local treatment of

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