THIAMINE REQUIREMENT OF MAN
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Excerpt
Several investigators have shown that the extent of urinary excretion of thiamine is an index pf its status in the nutrition. In thiamine clearance studies in man Melnick and Field1 demonstrated that all the subjects in their normal group, but none in the deficient group, excreted in excess of 50 micrograms of total thiamine during the four hour period following parenteral administration of 540 micrograms of thiamine.
Objective thiamine balance studies were made by Melnick2 in man to detect the requirements for thiamine and the incidence of inadequate intake among apparently normal subjects. A study on 39 male and 33 female persons subsisting on adequate diets indicated good correlation between the urinary excretion of thiamine and the adequacy of the dietary level prior to conduction of tests. The normal person who consumes an adequate diet apparently tends to excrete part of the extra dietary thiamine in the urine.
