Clinical Science
Since this article does not have an abstract, we have provided the first 150 words of the full text.
Excerpt
Urinary Lactic Dehydrogenase Activity I. Screening Method for Detection of Cancer of Kidneys and Bladder
Warren E. C. Wacker, M.D., and Lionel E. Dorfman, M.D., Boston
LACTIC DEHYDROGENASE ACTIVITY (LDH) X has been reported to be present in urine,1-3 but its presence has not previously been utilized in diagnosis. LDH activity in serum and other body fluids, such as pleural effusions and ascitic fluid, however, has been used widely in the diagnosis of a large number of diseases including acute myocardial infarction,4,5 pulmonary embolism,6,8 and cancer.7,8 The present study demonstrates that an increased LDH activity in urine provides a potent diagnostic screening method for detection of malignant tumors of the kidneys and bladder.
The present successful development of an adequate method for measurement of LDH activity in urine depended upon recognition and elimination of substances that inhibit LDH activity and that have been found in all
Footnotes
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From the Biophysics Research Laboratory of the Division of Medical Biology, Department of Medicine, Harvard Medical School, and the Peter Bent Brigham Hospital.
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Assistant Professor of Medicine, Harvard Medical School, Senior Associate in Medicine, Peter Bent Brigham Hospital, and investigator, Howard Hughes Medical Institute (Dr. Wacker). Research Fellow in Surgery (urology), Harvard Medical School, Assistant in Surgery (urology), Peter Bent Brigham Hospital, and recipient of F.N.G. Starr Memorial Scholarship, University of Toronto. On leave of absence from Department of Surgery, University of Toronto (Dr. Dorfman).
