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JAMA. 1963;184(7):587-590. doi: 10.1001/jama.1963.73700200008025a

Thrombotic Thrombocytopenic Purpura in Pregnancy

  1. Walter Solomon, MD;
  2. Daniel S. Turner, MD;
  3. Charles Block, MD;
  4. A. Charles Posner, MD
  1. New York
  2. From the departments of laboratories, medicine, and obstetrics, the Bronx Hospital.; Dr. Block is a Fellow of the National Heart Institute, National Institutes of Health.

Since this article does not have an abstract, we have provided the first 150 words of the full text.

Excerpt

THROMBOTIC THROMBOCYTOPENIC PURPURA (TTP) is being diagnosed with increasing frequency. Five cases have been reported in which the disease occurred as a complication of pregnancy.1-4 We are here presenting a synopsis of these cases and are adding a sixth case together with a discussion of diagnosis and management.

Report of a Case On Jan 20, 1961, a 28-yr-old pregnant woman, Gravida 6, Para 4, whose expected date of confinement was Feb 20, came to The Bronx Hospital in active labor. Fifteen minutes after admission a 4 lb 6 oz (2.0 kg) girl was delivered spontaneously. Intrapartum bleeding was estimated at less than 150 cc. The only notable signs at this time were pallor (Table 1) and a blood pressure of 140/90 mm Hg. A blood transfusion had to be discontinued after 800 cc because of a chill and vomiting. Rectal temperature was 100 F (37.8 C) and pulse rate

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