Metabolism of the Transplanted Heart
Effect of Excision and Reimplantation on Myocardial ATPase and Glucose-6-Phosphate Dehydrogenase Activity
- Theodore Cooper, MD, PhD;
- Max Jellinek, PhD;
- Vallee L. Willman, MD;
- C. Rollins Hanlon, MD
Since this article does not have an abstract, we have provided the first 150 words of the full text.
Excerpt
The autotransplanted heart, while free of rejection problems peculiar to homotransplantation, presents functional abnormalities1,2 which may extend to cardiac failure during the postoperative period.3 Nevertheless, many animals tolerate complete excision and reimplantation of the heart indefinitely.4 The intrinsic adaptations required of the heart during the postoperative period are incompletely understood. We have, therefore, surveyed the effect of the operation on the activities of certain myocardial enzyme systems. This report details our experience with the myocardial adenosine triphosphatase (ATPase) and glucose-6-phosphate dehydrogenase activity.
Methods Cardiac excision and reimplantation (orthotopic autotransplantation) was done in five dogs. This operation, described previously,5 involves transection of the aorta, pulmonary artery, venae cavae, and left atrium, after which the heart is sutured into its original position. With the animal under general anesthesia the heart is rapidly excised and frozen in dry ice after separation into atrial, ventricular, and septal components. This was
Footnotes
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Read before the session on transplantation of the Fourth Multiple Discipline Research Forum during the 113th annual convention of the American Medical Association, San Francisco, June 24, 1964.
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Reprint requests to 1325 S Grand Blvd, St. Louis 63104 (Dr. Cooper).
