Physicochemical and Biochemical Aspects of Pharmacology
- Bernard B. Brodie, PhD
Since this article does not have an abstract, we have provided the first 150 words of the full text.
Excerpt
There are two facets to the problem of the biochemical and physical aspects of drug actions, the influence of drugs on the body and the influence of the body on drugs. In the past, pharmacology has emphasized the action of drugs on the living organism. But to be effective, a substance must have characteristics that allow it to reach its site of action in adequate concentration and to remain there for a suitable period of time. For this reason, we become concerned with the physical and biochemical factors that determine the duration of drug action.
About 25 years ago, when I first became interested in the fate of drugs, I felt like the bat in Aesop's fable. Journals of pharmacology showed considerable reluctance in associating themselves with this "biochemical" topic, while biochemical journals refused these "drug" papers outright. But over the years pharmacology has broadened and these sort of studies
Footnotes
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Presented as a 1967 Albert Lasker Basic Research Award Lecture at the New York University Medical Center, New York, Nov 9, 1967.
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Reprint requests to Laboratory of Chemical Pharmacology, National Heart Institute, Bethesda, Md 20014.
