Hydroxyurea in Nasopharyngeal Cancer
- George J. Lucas, MD;
- Wolfgang Lehrnbecher, MD
Since this article does not have an abstract, we have provided the first 150 words of the full text.
Excerpt
To the Editor:— Due to the anatomic location, malignant nasopharyngeal tumors are frequently silent for some time and are only recognized when they have extended beyond the limit of surgical correction. Hydroxyurea (Hydrea) has been found particularly useful for chemotherapy of head and neck malignancies in combination with irradiation.1,2
Report of a Case:— In 1967 a 53-year-old Chinese psychiatric patient (schizophrenic) was noted to have a dense leukoma in the right cornea relative to an ulcer which had been cauterized about five years before. A disturbance in extraocular motility was manifested by sixth nerve palsy bilaterally. Approximately seven months later serosanguineous discharge and difficulty in swallowing occurred. Enlarged lymph nodes over the posterior triangle were noted bilaterally.
X-ray films of the sinus and skull revealed marked tumor invasion in the base of the skull and paranasal sinuses, later diagnosed as a poorly differentiated infiltrating squamous cell carcinoma. An extrinsic compression
