Chronic Granulomatous Disease of Childhood in a 23-Year-Old Man
- Henry H. Balfour Jr., MD;
- James J. Shehan, MD;
- Lt Col Carl E. Speicher, MC;
- Emanuel Kauder, MD
- USAF
- From the departments of pediatrics (Dr. Balfour) and internal medicine (Dr. Shehan) and Laboratory Services (Lt Col Speicher). USAF Medical Center, Wright-Patterson AFB, Ohio: and the Department of Hematology and Oncology (Dr. Kauder), the Children's Medical Center, Dayton, Ohio. Dr. Balfour is now a postdoctoral fellow in infectious disease in the Department of Pediatrics, University of Minnesota Medical School, Minneapolis. Dr. Shehan is now in Omaha, Neb.
Abstract
A 23-year-old man with a history of recurrent bacterial and fungal infections since age 12 was shown to have a functional leukocyte defect similar to that found in children with chronic granulomatous disease. A liver biopsy revealed discrete granulomata. The documentation of this case calls attention to the possibility that there may be a mild form of chronic granulomatous disease and that recurrent bacterial infection in the adult may be due to a functional disorder of polymorphonuclear leukocytes.
Footnotes
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The views expressed herein are those of the authors and do not necessarily reflect those of the US Air Force or Department of Defense.
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Reprint requests to Box 437 Mayo Memorial, Minneapolis 55455 (Dr. Balfour).
