Clindamycin and Diarrhea
- Gary D. Friedman, MD;
- Marie J. Gérard, MD;
- Hans K. Ury, PhD
Abstract
Of 298 outpatients receiving clindamycin for a variety of indications, diarrhea developed in ten (3.4%); none were diagnosed as having pseudomembranous colitis. This is well within the range of relative frequencies of diarrhea development (0% to 22.2%) reported in 45 previous studies. Reliance solely on computer-recorded instances of diarrhea yielded a substantial underestimate of diarrhea occurrence, but the rate was still significantly higher (P <.05) in clindamycin users than in nonusers.
(JAMA 236:2498-2500, 1976)
Footnotes
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Reprint requests to Department of Medical Methods Research, The Permanente Medical Group, 3779 Piedmont Ave, Oakland, CA 94611 (Dr Friedman).
