Elevated Platelet-Associated IgG in Thrombotic Thrombocytopenic Purpura
- Lt Comdr John Morrison, MC;
- Robert McMillan, MD
Abstract
A 41-year-old woman with thrombotic thrombocytopenic purpura (TTP) was treated with prednisone and splenectomy with complete recovery from her illness. Analysis of the patient's platelets for immunoglobulins showed abnormally elevated levels in the range of those seen in thrombocytopenic patients with systemic lupus erythematosus, immune vasculitis, and infectious mononucleosis. This finding is consistent with the concept that the immune system may play a role in the pathogenesis of TTP.
(JAMA 238:1944-1945, 1977)
Footnotes
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The opinions or assertions expressed herein are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department or the naval service at large.
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Reprint requests to Department of Internal Medicine, Naval Regional Medical Center, San Diego, CA 92134 (Dr Morrison).
