Reversible Acute Renal Failure Induced by Indomethacin
- Siang Y. Tan, MD;
- Ronald Shapiro, MD;
- Mary Ann Kish, MD
Abstract
Acute renal failure occurred during indomethacin therapy in a patient with chronic pyelonephritis. Urinary prostaglandin E2 levels were diminished but returned to normal after discontinuation of drug therapy and recovery of renal function. Prostaglandins may be critical for the integrity of renal function, and the use of prostaglandin inhibitors such as indomethacin and other nonsteroidal anti-inflammatory drugs may be deleterious in patients with underlying renal disease.
(JAMA 241:2732-2733, 1979)
Footnotes
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Reprint requests to Division of Nephrology, Department of Medicine, Medical College of Ohio, CS 10008, Toledo, OH 43699 (Dr Shapiro).
