Noncontraceptive Estrogens and Myocardial Infarction in Young Women
- Lynn Rosenberg, ScD;
- Dennis Slone, MD;
- Samuel Shapiro, MB FRCP(E);
- David Kaufman, MS;
- Paul D. Stolley, MD;
- Olli S. Miettinen, MD
- From the Drug Epidemiology Unit (Drs Rosenberg, Slone, and Shapiro, and Mr Kaufman), Boston University Medical Center; the Department of Research Medicine, University of Pennsylvania School of Medicine, Philadelphia (Dr Stolley); and the Department of Epidemiology, Harvard School of Public Health, Boston (Dr Miettinen).
Abstract
The effect of noncontraceptive estrogens on the risk of myocardial infarction (MI) in women aged 30 to 49 years was investigated in 477 women with first infarctions and in 1,832 hospital control subjects. There was little evidence of an effect: overall, the estimated relative risk of acute MI for women who had used noncontraceptive estrogens in the preceding month, after allowance for potential confounding factors, was 1.0 (95% confidence interval, 0.6 to 1.7); the corresponding estimate for women who had discontinued use more than one month previously was 1.2 (0.8 to 1.8). There was also no apparent association in various subgroups, including women who smoked heavily and those who had no identified predisposition.
(JAMA 244:339-342, 1980)
Footnotes
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Reprint requests to Drug Epidemiology Unit, 777 Concord Ave, Third Floor, Cambridge, MA 02138 (Dr Rosenberg).
