Single-Dose Amoxicillin Therapy for Urinary Tract Infection
Multicenter Trial Using Antibody-Coated Bacteria Localization Technique
- Robert H. Rubin, MD;
- Leslie S. T. Fang, MD, PhD;
- Stephen R. Jones, MD;
- Robert S. Munford, MD;
- J. M. Slepack, MD;
- Patricia A. Varga, MA;
- Linda Onheiber, PA;
- Catherine L. Hall, MS;
- Nina E. Tolkoff-Rubin, MD
- From the Medical Services, Massachusetts General Hospital, Boston (Drs Rubin, Fang, and Tolkoff-Rubin and Ms Varga); the Medical Services, Parkland Memorial Hospital, Dallas (Dr Munford and Ms Hall); the Kaiser-Permanente Health Program of Oregon, Portland (Dr Slepack and Ms Onheiber); the Department of Medicine, Harvard Medical School, Cambridge, Mass (Drs Rubin, Fang, and Tolkoff-Rubin); the Department of Medicine, University of Texas Southwestern Medical School, Dallas (Dr Munford); and the Department of Medicine, University of Oregon Health Sciences Center, Portland (Drs Jones and Slepack).
Abstract
Urine specimens from 134 women with acute, uncomplicated urinary tract infection at three medical centers were examined by the antibody-coated bacteria (ACB) assay. Patients with negative assays (suggesting bladder infection alone) were randomized to receive either a single 3-g oral dose of amoxicillin trihydrate or conventional ten-day courses of sulfamethoxazole-trimethoprim or oral ampicillin sodium. Comparable results were obtained with the three regimens for ACB-negative infection: 90% eradication of the original organism with single-dose amoxicillin, 100% with sulfamethoxazole-trimethoprim, and 96% with ampicillin. The overall incidence of ACB positivity was 32.1%, ranging from 8% to 63% at the three institutions. This difference seemed to be related to the ease of access to medical care: women with easy access having low rates of ACB positivity and those with poor access having high rates.
(JAMA 244:561-564, 1980)
Footnotes
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Presented in part at the 18th Interscience Conference on Antimicrobial Agents and Chemotherapy, Atlanta, Oct 2, 1978.
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Reprint requests to Infectious Disease Unit, Massachusetts General Hospital, Boston, MA 02114 (Dr Rubin).
