The Effect of Starvation and Repletion on Plasma Fibronectin in Man
- Rhonda L. Scott, PhD;
- Paul R. Sohmer, MD;
- Murdo G. MacDonald, MD
- From the Divisions of Combat Casualty Care (Dr Scott) and Blood Research (Drs Sohmer and MacDonald), Letterman Army Institute of Research, and the Department of Medicine, Letterman Army Medical Center (Dr MacDonald), Presidio of San Francisco. Dr Sohmer is now with St Thomas Hospital, Nashville, Tenn.
Abstract
Since circulating fibronectin levels have been associated with trauma, the relationship between fibronectin and fasting was investigated. Eighteen healthy but obese patients fasted for 21 days, and plasma fibronectin levels were determined weekly. Fibronectin concentrations were reduced throughout the fast, but increased after food intake. This starvation-induced decrease in fibronectin may be a deleterious mechanism associated with physiological insults.
(JAMA 1982;248:2025-2027)
Footnotes
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Presented in part at the American Federation for Clinical Research (Eastern Section), Boston, Oct 24, 1981.
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The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army or the Department of Defense.
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Reprint requests to Division of Combat Casualty Care, Letterman Army Institute of Research, Presidio of San Francisco, CA 94129 (Dr Scott).
