Splenic Syndrome at Mountain Altitudes in Sickle Cell Trait
Its Occurrence in Nonblack Persons
- Peter A. Lane, MD;
- John H. Githens, MD
Abstract
Six consecutive cases of splenic syndrome at mountain altitudes in persons with sickle cell trait are reported and the literature is reviewed. All six cases occurred in men who experienced the acute onset of severe left-upper-quadrant abdominal pain within 48 hours of arrival in Colorado from lower altitudes. All six patients were phenotypically nonblack. Three patients experienced their symptoms at moderate altitudes of 1,609 to 2,134 m (5,280 to 7,000 ft) above sea level. All recovered with medical management and none required splenectomy, although functional hyposplenia was a sequela in at least one patient. The possibility that nonblack persons with sickle cell trait may be at greater risk than black persons with sickle cell trait for the development of splenic syndrome at moderate altitude is discussed.
(JAMA 1985;253:2251-2254)
Footnotes
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Read in part before the Western Society for Pediatric Research, Carmel, Calif, Feb 10, 1984.
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Reprint requests to 4200 E Ninth Ave, Box C220, Denver, CO 80262 (Dr Githens).
