Isoniazid Overdose in the Cambodian Population of Olmsted County, Minnesota
- Paul D. Blanchard, MD;
- Joseph D. C. Yao, MD;
- Donald E. McAlpine, MD;
- Richard D. Hurt, MD
Abstract
Eight cases of suicidal isoniazid overdose by Cambodian refugees are reviewed. In all patients generalized seizures and metabolic acidosis developed. Treatment included supportive measures and intravenous pyridoxine hydrochloride. There were no deaths. Psychiatric evaluation of each patient revealed usual and extraordinary life and social adjustment stresses. Indochinese immigrants are a subpopulation at risk for isoniazid overdose.
(JAMA 1986;256:3131-3133)
Footnotes
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Reprint requests to Mayo Clinic, 200 First St SW, Rochester, MN 55905 (Dr Hurt).
